Combination Vaccines:
5-in-1 and 6-in-1 Vaccines

baby 6-in1 vaccine infection

What are Combination Vaccines?

Combination vaccines are formulated by combining multiple vaccines that fight against 4,5 and 6 diseases into 1. These combinations have been proven to be safe and effective.

What are the 5-in-1 and 6-in-1 Vaccines For Babies?

The 5-in-1 and 6-in-1 vaccines for babies combine vaccines against 5 and 6 diseases.

Both vaccines are subsidised by the Government for Singapore citizens. For more information, you may call our SBCC Baby & Child clinics.

6-in-1 Vaccine for Babies

  • Vaccines against:
    – Diphtheria
    – Pertussis
    – Tetanus
    – Polio
    – Haemophilus Influenzae type B (Hib)
    – Hepatitis B
  • 3 doses at 2,4 and 6 months old
  • For babies who has opted to vaccinate Hepatitis B separately, the 5-in-1 vaccine will be given at 3, 4 and 5 months old.

5-in-1 Vaccine for Babies

  • Vaccines against:
    – Diphtheria
    – Pertussis
    – Tetanus
    – Polio
    – Haemophilus
  • 1 dose (booster of 6-in-1 vaccine) at 18 months old

Diseases 5-in-1 & 6-in-1 Vaccines Protection Against


Diphtheria is an infectious disease of the nose and throat that is common among young children. Diphtheria symptoms can lead to life-threatening complications, even death, in children who are not immunised.


Caused by the neurotoxin produced by the bacteria that grow in dirty wounds. This results in muscle spasms, especially of the jaw, causing difficulty in breathing.

Pertussis (Whooping Cough)

A disease of the respiratory tract. The baby will have coughing spells that may last for 4-8 weeks and may end up in death.


Poliomyelitis, or polio, attacks the nervous system, resulting in a crippling condition. Children younger than 5 years old are more likely to contract the virus than any other group. A highly infectious disease, it transmits through consumption of contaminated food or drink.

Haemophilus Influenza Type B

It is spread by respiratory droplets and causes severe pneumonia, meningitis, ear infection and other serious infections. Most common in children under 5 years old. Hib also causes potentially severe inflammatory infections of the face, mouth, blood, epiglottis, joints, heart, bones, peritoneum, and trachea.

Hepatitis B (only in 6-in-1 Vaccine)

Hepatitis B is a contagious liver disease caused by the hepatitis B virus. When a person is first infected with the virus, he or she can develop an “acute” (short-term) infection. Acute hepatitis B refers to the first 6 months after someone is infected with the hepatitis B virus. This infection can range from a very mild illness with few or no symptoms to a serious condition requiring hospitalization.